In September 2024, the World Health Organization (WHO) released new guidance on preventative treatment for tuberculosis (TB). Thanks to new evidence from two randomised controlled clinical trials, the WHO now recommends that contacts of people with multidrug-resistant TB take six months of daily levofloxacin. In this episode of the Trial Talk podcast, we find out more about the TB-CHAMP and VQUIN trials. We also learn how the teams came together to combine their data and strengthen their evidence, using new statistical methodologies developed at the MRC Clinical Trials Unit at UCL. The episode features interviews with Anneke Hesseling, Principal Investigator for TB-CHAMP, based at Stellenbosch University, and Trinh Duong, based at the MRC CTU at UCL, the trial statistician for TB-CHAMP and lead for the combined data analysis with VQUIN.

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9/23/2024

In the first episode of our new Trial Talk series, Hanif Esmail and Conor Tweed take over the microphones to interview Andrew Nunn and Sarah Meredith, who have both recently retired from the Unit, having spent a combined total of 92 years working in the field of tuberculosis (TB). As we celebrate Andrew and Sarah’s long and accomplished careers, we’ll dive into the history of TB clinical trials and muse on the future of TB research. For more information and to access the transcript: www.mrcctu.ucl.ac.uk/news/news-stor…inical-trials/ Check out our earlier podcast episodes about TB trials, also featuring Andrew Nunn: • Trial-talk-podcast – The-stream2-trial-how-should-we-treat-multi-drug-resistant-tuberculosis • Trial-talk-podcast – Andrew-nunn-talks-medical-statistics-tb-and-algerian-nomads-part-1 • Trial-talk-podcast – Andrew-nunn-talks-medical-statistics-tb-and-algerian-nomads-part-2 For questions or feedback on the series, message us at mrcctu.engage@ucl.ac.uk As a listener, you

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1/26/2024

For World TB Day, this episode explores the global burden of tuberculosis (TB) and how growing antibiotic resistance can complicate treatment options. Andrew Nunn, a Professor of Epidemiology, discusses his work on the STREAM2 trial, which investigated how treatment for multi-drug resistant TB could be shortened and made more acceptable for patients. Further information is available on the STREAM Stage 2 study page at www.mrcctu.ac.uk and results from STREAM2 are published open access in The Lancet.

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3/23/2023

Leading tuberculosis physician, academic and advocate Prof Madhukar (Madhu) Pai of McGill University gives a special UCL-TB guest lecture. Prof Pai's talk took place on 9th April 2019. Jacqueline Huh of Stop TB followed Prof Pai's talk with an update on the Stop TB organisation's TB innovation work.

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4/30/2019