2 items found in 1 pages
Professor Sam Janes - Detecting lung cancer earlier: Crawling to the SUMMIT
Professor Sam Janes Wellcome Trust Senior Fellow in Clinical Science; Professor of Respiratory Medicine, UCL Respiratory Head, Respiratory Research Dept, UCL Rethinking Cancer | UCL Cancer Domain Symposium Monday 13 May 2019 Cancer detection: the earlier the better? Cancer remains one of the major causes of morbidity and premature death worldwide; one in two people in the UK born after 1960 will be diagnosed with some form of cancer during their lifetime. UCL has a proud track record in addressing the societal, technical, and health challenges of cancer and in exploring its underling biology. This symposium, invited our broad community to assemble for the first time at scale to consider challenges and opportunities in cancer research, prevention and treatment, from biological, clinical, technical, economic and societal perspectives.
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6/4/2019
Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution
The immune system is constantly on the lookout for diseased cells. Every cell in our body has signals on their surface that reach out to immune cells, letting them know if everything is ok, or if the cell is unhealthy. Signals from diseased cells will cause the immune system to attack and kill those faulty cells. But in many lung cancers, the cancer cells lose about half of those signals to the immune system. This lets the cancer cells hide from the immune attacks, and allows the cancer to keep growing. Researchers have developed a computational toolset to help investigate how many of these signals to the immune cells are left on a cancer cell, based on DNA sequencing information. Hopefully this will help us develop more focused immune therapy in the future. First author: Rachel Rosenthal Corresponding authors: Professor Charles Swanton and Dr Nicholas McGranahan Research paper: http://www.cell.com/cell/fulltext/S0092-8674(17)31185-6
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11/3/2017