TINs Webinar: Phage display technology for the identification of peptides and glycopeptide ligands

Phage display is a recombinant screening technology that involves the construction of bacteriophage libraries that express large numbers (1*10^11) of peptides or proteins as fusions to the major or minor coat proteins of bacteriophage species such as M13. Phage display is routinely used in the pharmaceutical industry to develop fully human antibodies against a range of different diseases targets, including cancer and inflammatory diseases. Dr Chris Morris, from the School of Pharmacy, presented examples of how phage display can be applied to the identification of peptide-based motifs for targeting biological structures at three different length scales – whole cells in melanoma skin cancer, individual glycan-binding proteins in human lung infections and subcellular, non-canonical DNA structures.